The Rabbitohs overcame a torrid first half with a man in the sin bin to storm home with a 26-point victory, highlighted by a stirring performance from centre Campbell Graham.
The Coogee Wombats junior continued his try-scoring form at Suncorp Stadium with a hat-trick parking in his fifth try at the venue in 2023, while taking the competition lead with eleven to his name.
Fullback Latrell Mitchell had another busy outing with two tries to his name and four goals, while front rower Junior Tatola made a welcomed return to the field.
The Rabbitohs found themselves under pressure early, and it was desperation from Cameron Murray that saw the skipper sent to the sin bin for a professional foul, with Brisbane taking an early 2-point lead with a penalty goal.
Welcoming the challenge ahead, the men from Redfern struck back immediately with the best possible reply, with a neat grubber from Lachlan Ilias taken by Campbell Graham, giving the Rabbitohs a 6-2 lead.
The back and forth continued in this free-flowing contest, with Jesse Arthurs crossing for the Broncos out wide with the sides locked up at 12-apiece after as many minutes.
Off-the-cuff play troubled the Rabbitohs out wide, with the hosts narrowly missing out on another try with Selwyn Cobbo losing the ball over the line as Murray returned to the field of play.
Ill discipline hurt the Red and Green on both sides of the ball, with desperate defence denying Kurt Capewell and Keenan Palasia - surviving another raid as Cobbo was denied once more.
Junior Tatola looked to swing momentum with a strong opening run as both sides entered an arm wrestle - with Alex Johnston shutting down another threatening charge from their opponents.
With the intensity ramping up close to half-time, both sides came together in heated exchanges as errors with the ball in hand cruelled the Rabbitohs while Brisbane failed to ice their changes.
A Captain's Challenge five minutes from the break saw South Sydney with a scrum feed just ten minutes from the line, and the lead changed once more as Graham charged over for his second for the night off Damien Cook.
A Captain's Challenge five minutes from the break saw South Sydney with a scrum feed just ten minutes from the line, and the Rabbitohs took a 12-6 half-time lead as Graham charged over for his second for the night off a pass from Damien Cook.
The roll-on continued just minutes into the second half, with a towering kick from Cody Walker finding Latrell Mitchell, who swooped onto the ball to slam it down, with his conversion giving the Rabbitohs an 18-6 lead.
Brisbane found themselves down a man the following set after Farnworth was found tripping Graham, and while Johnston looked likely to add his name to the scoresheet, a desperation tackle saw him lose possession over the line.
That mattered little, however, as a bullet-like pass from Mitchell saw winger Taane Milne careening down the sideline before throwing the Steeden inside to Graham, who completed his hat-trick.
Damien Cook powered over the line for the second time in as many weeks, only for the try to be overturned by the Bunker, while the Rabbitohs survived a long-range break from the Broncos on the following set.
Not deterred by the recent miss, the halves stood up with Ilias cutting out wide to Graham, who sent the ball back inside to Cody Walker for the side's fifth try of the night with a quarter of the match remaining.
No doubt Ron Coote would have been proud of the cover defence shown as Isaiah Tass and Mitchell sent Reece Walsh into touch as the fullback went over before their urgency shut down the Broncos after multiple set restarts on their line.
Isaiah Tass collected a wayward kick to streak downfield, and the killer blow came a few tackles later as Mitchell bagged his second after engineering a clever fifth-tackle play.
Cook was denied once again following a dubious knock-on call, with the Rabbitohs keeping their opponents to just one try and wrapping up a well-earned 32-6 victory.
Front rower Junior Tatola made his long-awaited return to the field following a frustrating opening two months of the season via the interchange bench.
The Rabbitohs have now won six out of the last ten matches against the Brisbane Broncos dating back to 2018.
Campbell Graham's hat-trick marked his fifth try in just two games at Suncorp in 2023, having scored a brace in the 36-14 win against the Dolphins three weeks prior.
The victory also marked the third consecutive victory for the Red and Green at Suncorp Stadium, equalling the Club's record in 2013-2015 and in 2021.
Cameron Murray was pinged for a professional foul close to the line, giving the Broncos a 2-nil lead through a penalty goal in the 4th minute.
The Rabbitohs replied through Campbell Graham just minutes later, with a clever grubber kick from Lachlan Ilias giving the side a 6-2 lead after 8 minutes.
Brisbane struck back through Jesse Arthurs, who crossed out wide to level the scores at 12-all after as many minutes.
A Captain's Challenge five minutes before half-time saw the Rabbitohs with a scrum feed ten metres from the line, and it was Campbell Graham charging onto a ball to give the side a 12-6 lead at the break.
The momentum continued just three minutes into the second half as Latrell Mitchell swooped on a loose pass to give the Rabbitohs a twelve-point lead after 44 minutes.
Mitchell had his hands all over the next four-pointer, sending a bullet-like pass to Taane Milne who turned inside to give - Graham his third of the night.
Lachlan Ilias and Campbell Graham combined to send Cody Walker over soon after for the side's fifth try with 20 minutes remaining.
Mitchell wrapped up the victory after a clever fifth-tackle play saw him pounce over the line with just under ten minutes to go following a long-range break from Isaiah Tass.
Play of the Game
It was a two-pronged play that saw the Rabbitohs not only claim the lead heading into half-time but also swing the momentum back in their favour.
An off-the-cuff last-tackle play saw referee Ashley Klein call for a Rabbitohs knock-on, but that was until Cameron Murray called for a Captain's Challenge which revealed a knock-on from Broncos centre Herbie Farnworth.
Now with a scrum feed ten metres out with five minutes remaining in the half (and the scores locked at 6-all) the Red and Green took their opportunity with both hands as Damien Cook put Campbell Graham away in the blink of an eye.
The move saw the towering centre over for his second try of the night, handing the Red and Green the lead in what was a back-and-forth contest, paving the way for the hard-earned victory.
The South Sydney Rabbitohs will prepare themselves for another test when they face the Melbourne Storm on Saturday night back at Suncorp Stadium during the NRL's Magic Round.