The round seven match between the South Sydney Rabbitohs and Penrith Panthers on Thursday night will be relocated from Campbelltown Stadium to Netstrata Jubilee Stadium.
NRL Head of Football Graham Annesley said the game would be played on a fresh surface.
"Campbelltown Stadium has had an extremely heavy workload over the last month, with some games played in wet conditions. The staff at Campbelltown Stadium have done an excellent job hosting a number of teams," he said.
