After disappointing losses, Melbourne and South Sydney each have a point to prove in this heavyweight duel.
The Storm, who were soundly beaten by the Raiders in round three, have conceded they need to tweak their structure to suit the ad-lib nature of the game due to the new six-again rule.
The Rabbitohs, on the other hand, were outclassed by the Roosters - marking consecutive defeats - and need to build momentum.
Storm: Marion Seve is out of the Storm team, with Brenko Lee (No.18) to start in the centres. In a change in the forwards, Brandon Smith (No.14) will start the match, with Christian Welch dropping back to the bench. Seve and Darryn Schonig were the two players left out an hour before kick-off. Nelson Asofa-Solomona is suspended.
Rabbitohs: The final squad announcement from the Rabbitohs confirmed that Liam Knight is out of the starting side, with Ethan Lowe (No.15) moving into the run-on team. Keaon Koloamatangi will make his NRL debut from the interchange bench. Bayley Sironen and Bryson Goodwin were the last players left out of the squad an hour before kick-off.
It's always intriguing when Damien Cook and Cameron Smith, the current and former Australian Test hookers, lock horns. But even more so this time given the new six-again rule and its impact on dummy-half play. One would expect the quick ruck speed to suit the dynamic Cook more than Smith, but the all-time legend has the nous and experience to exploit it too.