Despite a loss last week the Rabbitohs will be heartened with their showing againt the Broncos while the Titans come in after one of their most disappointing performances with a team torn apart by injuries and Origin commitments.
With the Titans fielding an understrength and awkward looking team, Maguire and his men will be looking to use this opportunity to set their season straight after a disappointing start to the season. However, the the Rabbitohs boss is quick to underline that his team are keeping the focus in-house ahead of the clash.
"We're working extremely hard to get the results that they're (the Members and fans) after. We're looking forward to having a really strong performance against the Titans and playing our style of football," said Maguire.
"Obviously, defensively we're working hard together to make sure we have that same effort, same scramble and same desire to repel everything that comes at our line.
"Really looking forward to getting out on Friday and getting that result that we know we're after."
The mass of changes that the Titans have been forced to make will ensure they bring a simplified game-plan to ANZ Stadium that should play straight into the hands of the Rabbitohs.
South Sydney's direct, power-packed approach threatened to upset the Broncos last week and if Tom and George Burgess can provide a similar platform on Friday night there's no way the Titans will be able to quell their momentum. This game in particular will be won in the middle which is where the Rabbitohs love to play it most.
Rabbitohs coach Michael Maguire has named the same 17 as they started against the Broncos last week with Tyrell Fuimaono starting in the back row and Kyle Turner on the bench while Titans coach Neil Henry has been forced to make a total of nine changes to the 21-man squad he named last week.
William Zillman starts at fullback for the first time in 12 months, John Olive makes his first appearance for 2017, Chris McQueen has been named at five-eighth, Pat Politoni will make his club debut at hooker and Kevin Proctor returns from a four-game club-imposed suspension in the back row.
It's been rare in recent years with the Rabbitohs taking home games to Cairns and Perth that these two teams have met in Sydney but it's an assignment the Titans have performed fair in, winning three of the six matches played at ANZ Stadium.
The Rabbitohs have a slight edge in the head-to-head record although the result is more often than not decided by a narrow margin, with the winning margin in 11 of the 14 games eight points or less. The most recent meeting was a thriller in Perth, where South Sydney trailed 18-0 before forcing golden point where they thought an Adam Reynolds field goal had stolen an unlikely win. The field goal was denied due to an illegal block by Nathan Brown and two minutes later Ashley Taylor was the match-winner for Gold Coast.