The boys in red and green have maintained their undefeated season so far, scoring five tries to one in the Preliminary Final to book their spot in next weekend's Grand Final.
The South Sydney boys dominated the first half, scoring three tries to nil to establish a 16-nil lead at the break.
Johnathan Tufuga scored the first try after five minutes, followed by an 18th minute try to Reimis Smith and a 26th minute try to Cameron Murray. Siosifa Talakai converted the first and third tries to establish the 16 point advantage.
Jaiden Brown was strong in the halves, directing the play for the boys in red and green.
South Sydney started the half on fire with prop Gabriel Hamlin collecting a Jaiden Brown grubber kick for a try. Talakai converted to take the score out to 22-nil after 31 minutes.
The Panthers struck back in the 35th minute when centre Liam Murray scored next to the posts. Jonah Metuangaro converted taking the score to 22-6.
Talakai extended the lead in the 46th minute with a penalty goal, taking the score out to 24-6 with less than a quarter of the game to go.
With ten minutes to go, the South Sydney boys made the most of a Penrith error, with Reimis Smith scoring his try to take the score line out to 28-6.
Both sides wound down the clock, and the boys in red and green secured their spot in the Grand Final with a comfortable 22 point win.
Best for South Sydney were Brown, Smith, Talakai, Hamlin and Nat Butcher.
South Sydney side will now take on the winner of the Parramatta Eels vs Western Suburbs Magpies in the NSWRL Harold Matthews Cup Grand Final next weekend. Keep an eye on www.rabbitohs.com.au for more details this week.
South Sydney 28 (Reimis Smith 2, Johnathan Tufuga, Cameron Murray, Gabriel Hamlin tries; Siosifa Talakai 4 goals)
Penrith Panthers 6