Rabbitohs RTR13 captain Jason Clark registered a double, with South Sydney crossing the line on seven occasions compared to the Papuans two.
It was an ordinary start to the game, with the Rabbitohs kicking off dead on the full, followed by errors to both sides.
With the nerves of a new season set aside, the Rabbitohs tried to settle into a rhythm, with young halves Luke Keary and Justin Hunt forming a combination on the run.
In the ninth minute of play, second rower Ben Lowe crossed for the first try of the match, straightening the play and charging hard and fast at the line to score. Bryson Goodwin converted to take the score line to six-nil.
PNG struck back almost immediately, with halfback Israel Eliab scoring under the posts three minutes later, following through a chip kick to score. He converted his own try to level the scores at six-all.
A great charge from Rabbitohs hooker Apisai Koroisau in the 16th almost led to points, but it was PNG that would lead at the quarter-time break, with Eliab scoring his second try, this time a 70 metre intercept. He converted his try to take the scores to 12-6 to PNG after 20 minutes.
Dave Tyrrell copped an almighty hit to open the second quarter, but dusted himself off to get through a mountain of work and get his team back on the front foot. He scored a try in the 24th minute of play, bustling over from close range. Goodwin converted to level the scores at 12-all.
Ben Lowe was held up over the line in the 31st minute and Justin Hunt pulled off a magnificent cover tackle in the 33rd minute to keep PNG camped in their own 30 metre zone.
It paid dividends with Clark scoring his first try in the 34th minute, again burrowing over from close range. Bryson Goodwin converted to give the Rabbitohs a six-point advantage at the half time break.
The second half was all red and green.
Five minutes in Chris McQueen scored after spinning out of three tackles to score on the right, giving the Rabbitohs a 22-12 lead.
The forwards started to dominate, with George Burgess, Tyrrell, Clark and Kyle Turner all making inroads into the PNG defence, and Bryson Goodwin looking classy out wide in the centres. Apisai Koroisau was causing all sorts of issues for the Papua New Guineans from dummy half and when backing up the ball runner.
In the final quarter, Thomas Burgess made a long break, offloading to Greg Waddell who in turn shifted the ball to Apisai Koroisau, giving the Rabbitohs quality field position.
Aaron Gray would be the recipient of their good work, crossing in the left corner in the 64th minute. Goodwin converted to take the scores 28-12.
A rampaging charge by George Burgess in the 68th minute put the Rabbitohs back into a commanding position, and three minutes later North Sydney Bears player Bennett Leslie scored for South Sydney, making a short range charge on the left fringe.
Clark would score his second try in the 73rd minute after halfback Luke Keary broke the line in the middle of the field, putting Clark away under the black dot. Koroisau converted to finalise the score line at 38-12 in favour of the home side.
The Rabbitohs suffered no injuries from this game, and will now prepare to take on the Newcastle Knights at BCU International Stadium in Coffs Harbour next Saturday 16 February at 7pm.
South Sydney Rabbitohs 38 (Jason Clark 2, Ben Lowe, Dave Tyrrell, Chris McQueen, Aaron Gray, Bennett Leslie tries; Bryson Goodwin 4, Apisai Koroisau goals)
Papua New Guinea Residents XIII 12 (Israel Eliab 2 tries; Israel Eliab 2 goals)
In the under 20s trial match played earlier today (Saturday), the Penrith Panthers defeated the South Sydney Rabbitohs six tries to one at Erskineville Oval.
Fullback Will Paterson scored the only try for the Rabbitohs, with the Panthers winning the forward battle, giving the leg up for the full 90 minutes played across three thirds.